Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist — the cofactor used in that tissue cannot bind and so the receptor remains inactive — and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
My husband and I have been ttc for 6 years. Had bilateral tubal blockage. Had a lap done in January of 2013. TTC for 6 months with no success. My RE did a HSG yesterday. Dye showed slight dilation and we waited 5 minutes. And, YES, the dye went through the tubes (thank GOD), it went throught slowly, however, it did make it all the way through. I am grateful for that.
I just started my first round of Clomid 50 mg on CD3-7.
I am starting my clear blue ovulation monitoring (this am)
I am so excited. I am praying and believing for a miracle.
I have never used clomid before this. I am expecting a healthy BFP this month. I will keep everyone updated. If this doesn't work, RE wants me to go on Femara.
I chose to start with clomid first.
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