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The neurotoxin MPTP had been known earlier to cause PD-like symptoms (in humans and other primates, though not in rats) by interfering with complex I in the electron transport chain and killing dopaminergic neurons in the substantia nigra. However, further studies involving MPTP have failed to show development of Lewy bodies , a key component to PD pathology. Therefore, the mechanism behind MPTP as it relates to Parkinson's disease is not fully understood.  Because of these developments, rotenone was investigated as a possible Parkinson-causing agent. Both MPTP and rotenone are lipophilic and can cross the blood–brain barrier .
Hoodia has been around for a while and remains a bestselling weight loss product. A plant native to South Africa, hoodia has for many years been used by tribes there to suppress their appetites during long hunts. You’ll find that many conflicting reports on the effectiveness of hoodia for weight loss exist. One problem is that it’s sold by many companies, and you can’t always be sure you’re getting the real thing. Hoodia weight loss supplements are sold in capsule and tea form. It’s best that you go with a hoodia weight loss product that’s made by a reputable company so you don’t end up wasting your money on a weight loss product that doesn’t work. If you use authentic hoodia, you can count on losing weight through the suppression of your appetite.