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There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.

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This year, Studio Aandacht is running for 15 years and we have been together as a couple for 25 years. To celebrate this we treated ourselves to the newly opened Hide Out apartment in the Michelberger Hotel; The apartment consists of a big white wooden house built inside a huge loft situated in the back of the hotel. In this white house is a bedroom and top of the stairs a smaller bedroom, but we let the children stay at home in order to fully enjoy the sauna, rain shower and bathtub, and o yes on the left we also found a build-in kitchen. So you could actually hide out here if you want. In stead we went on being hero’s in Berlin…

Oxymetholone eye drops

oxymetholone eye drops

This year, Studio Aandacht is running for 15 years and we have been together as a couple for 25 years. To celebrate this we treated ourselves to the newly opened Hide Out apartment in the Michelberger Hotel; The apartment consists of a big white wooden house built inside a huge loft situated in the back of the hotel. In this white house is a bedroom and top of the stairs a smaller bedroom, but we let the children stay at home in order to fully enjoy the sauna, rain shower and bathtub, and o yes on the left we also found a build-in kitchen. So you could actually hide out here if you want. In stead we went on being hero’s in Berlin…

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